Abstract: Alterations in a variety of neurotransmitter systems have been identified in experimental models of epilepsy and in brain tissue from patients with intractable temporal lobe seizures.The availability of new high-affinity radioligands per-mits the study of some neuroreceptors in vivo with positron emission tomography (PET).Receptor imaging by PET offers distinctive advantages over the more established imaging methods,including improved chemical specificity and improved sensitivity in detecting changes in disease.Development of new PET methods for the study of presynaptic and postsynaptic neurotransmitter functions will offer unique opportunities in the study of epileptic mechanisms and the way to assess the ef-fect of antiepilepstics,which will bring light on complete overcome of epilepsy.