Ku蛋白在肿瘤发生中的作用及其靶向抑制策略

The role of Ku protein in the development of carcinogenesis and potential strategy for silencing it

摘要: Ku蛋白参与辐射诱导的DNA损伤修复,严重影响着肿瘤细胞的辐射敏感性。细胞内Ku蛋白异常表达与肿瘤发生和发展存在密切关系。目前,研究者试图抑制Ku蛋白表达来增强肿瘤细胞的辐射敏感性,为进一步靶向治疗奠定基础。

Abstract: The vital role of Ku protein is implement for DNA double strand break repair.Abnormal expression of Ku protein contributes to the development of carcinogenesis.The scientist are trying to enhance radiation-induced tumor control by inhibiting the Ku protein and have shown promising results.