Abstract: Recently, molecular imaging technologies detecting cell apoptosis in vivo are developing rapidly. The one of the most promising techniques to detect apoptosis in vivo is radionuclide imaging with radioLabeled annexin V. Due to the non-invasiveness, quantitation and other advantages, radionuclide tracing apoptotic imaging in vivo, which potentially has numerous valuable applications, has been greatly developed. The purpose of this paper is to review the application and development of cell apoptosis imaging with radionuclide tracing techinique.