电离辐射损伤与DNA修复基因

Damage of ionizing radiation and DNA repair gene

摘要: DNA辐射损伤直接影响复制、转录和蛋白质合成,进而影响细胞遗传、发育、生长和代谢等生命活动。DNA损伤还是突变的重要原因,而严重的突变可造成细胞癌变,导致肿瘤的发生。然而,生物体内存在着DNA损伤修复系统,其中DNA修复基因起着重要的作用。

Abstract: DNA damage after exposure to ionizing radiation has a direct effect on DNA replication, transcription and protein synthesis.Further, heredity, development and metabolism of the cells can be affected.DNA damage was an importance factor for mutation of cells, furthermore, carcinogen can be caused by severe mutation.However, there is a DNA repair system in the organism, and especially DNA repair gene plays an important role for DNA damage.This review will briefly present DNA re-pair gene and its function.