Abstract: Osteoporosis has many causes and different clinical presentations, all characterized by a loss of bone tissue to a level below that required for mechanical support of every day activities, resulting in nontraumatic fractures. Bone turnover may range from accelerated to severely reduced. Quantification of skeletal uptake of radionuclide have been evaluated to assess bone turnover. Different technical approaches have been described over years. Radionuclide quantitative bone scaning may be reasonably accurate and useful for the assessment of osteoporosis.