Abstract: The angiopoietin (Ang) family is important angiogenesis factor, including four members:Ang-1, Ang-2, Ang-3, Ang-4 It play critical role for blood vessel formation. With the progressing of studying about angiopoietion, it has been found that it take part in many diseasesis about angiogenesis. So it will be used widely in future in a lot of diseases,such as ischemic disease, tumor and wounding healing.