Abstract: Radioactive seeds have been used to treat pancreatic carcinoma in the early twenty cen-tries. Advances in the therapy of pancreatic carcinoma with radioactive seeds is slow because of the limitations of radiobiology and radiophysics, unsoundness of implantation technique and implantation plan system. As the radioactive seeds ¹²⁵I have been used since the late 1960s and radiobiology and radiophysics of radionucide has been studied profoundly, fast development of three-dimensional treatment plan system, useness of ultrasonically guided percutaneous implantation therapy for pancreatic carcinoma with radioactive seeds rise again.