急性核辐射对人的远期效应

The late effects of acute radiation injury on humans

  • 摘要: 内容仅涉及事故性急性核辐射的远期效应:1.日本原爆幸存者(包括宫内受照者约2800名)的流行病学调查结果,归纳为强关联、弱关联和无关联的远期效应。在第8~15孕周阶段接受1Gy照射的胎儿,约有43%会发生智力发育延迟,为受照0.01Gy以下的对比组危险度的50倍以上。对原爆人群各部位癌症的相对、绝对和归因危险作了介绍。对原爆幸存者受照射后怀孕所生子女(1946年5月以后出生),用(1)不利的妊娠结果、(2)死亡事件、(3)携带有性染色体异常儿童的频率、(4)携有由于基因突变引起的血液蛋白电泳变异体儿童的频率等遗传学指标提示,近爆心(<2000m)幸存者(>1Gy)所生儿童与远离爆心组(0.01~0.09Gy)相比,仅仅是预期趋势上有差别,实际上未发现有统计学意义的差异。即使如此,这两组儿童间的差异用上述4个指标中的前3个观察结果,估计了加倍剂量,平均数是1.56Sv,但是有争议。2.马绍尔群岛放射性落下灰受照居民医学随访近况,甲状腺疾病发病率高,而在日本原爆幸存者中则未见类似情况,估计与马绍尔群岛居民甲状腺因摄入放射性碘而照射量较大有关。3.日本福隆丸号渔民受落下灰照射后远后效应资料。4.美国Y-12工厂共8名受照者的远后效应:4例有放射性白内障,1998年时仅活存3例。5.前苏联切尔诺贝利核电站事故中急性放射病(ARS)病人远后效应:2例Ⅲ度ARS病人分别于照后第6年和第9年发生骨髓增生异常综合征(MDS)引起死亡,1例Ⅰ度ARS病人也于照后第9年诊断为MDS,另一例Ⅱ度ARS病人照后第11年发生急性单核细胞白血病。6.巴西137Cs事故5年后远期效应。

     

    Abstract: This paper presents the late effects of accidental acute radiationinjury on humans, such as 1. The late effects of Hiroshima and Nagasaki atomic bomb survivors including 2800 uterine exposure cases. The epidemiologic studies that revealed the late effects with strong association, weak association and no associations. Fetus exposed to 1Gy during their 8th-15th pregnancy week, 43% of whom may have retardation in intellectual development which are over 50 times of risk factor more than those control group. Based on DS86 organ absorbed dose, the RR, EAR, and AR of cancers at different positions are given for atomic bomb survivors population. Offsprings who were born after their parents exposed to atomic bomb explosion were analysed by (1) untoward pregnancy out-come; (2)death incident; (3)frequency of abnormal children carrying abnormal sex chromosome etc genetic indicators, the average doubling dosage was estimated to be 1. 56 Sv which has evoked much controversy. 2. M edical effects of exposure of humans beings to fallout radiation from a thermonuclear explosion at Marshall islands with high frequency of thyroid diseases morbidity because of high radioactive iodine uptake in thyroid. 3. Medical effects of 23 Japan “Dragon boat” fishermen exposed to fallout radiation. 4. Late effects of American Y-12 plant radiation accident survivors, 4 of them developed radiation cataract and only 3 was alive in 1998. 5. Late effects of Chemobyl nuclear plant accident survivors in former Soviet Union : MDS were developed at 6 th and 9th year later in two third degree ARS patients and also another one of 1st degree ARS was diagnosed. M DS as well. At 11 th year after the accident, acute monoblastic leukemia was diagnosed in patient after ARS of 2 nd degree. 6. Late effects of Brazil 137Cs accident.

     

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