Abstract: Objective To observe the the curative effects in younger with Graves disease therapied by ¹³¹I. Methods The dose of ¹³¹I is administrated with 1480~2220kBq/g of thyroid tissue which was decided by many factors that include the patient's Age, volume of thyroid, course and if antihyroid drug is administrated. The curative effects was classfide into four groups: complete remission, excellence, parts of remission, no effect. Results 47 were complete remission, 34 were excellence, 10 were the parts of remission and 0 was no effects. The total effective power was 100%. Conclusions Therapy with low-dose of ¹³¹I for younger with Graves' disease is an effect, simple and safe method. Repeating treatment with, ¹³¹I will improve the curative rate of Graves' disease in younger, and the incidence of hypothyroidism cannot be increased.