Abstract: Objective To investigate the curative effect and side reaction after 125 I seed implanted among tissue were treated the malignant neoplasm by radiography and chemotherapy.Methods Retrospective analysis the cancerous sufferer after the failure of radiography and chemotherapy, percutaneous puncture or intraoperative under gaze forward 125 I seed were implanted the bed of the tumour forever. Follow-up blood routine examination, symptom, sign, using USG or CT observe the change of the tumour and the distribution of the particles etc.Results In 3 cases, treat 2 cases,tumour reduced obviously, symptoms improved obviously, the face of the ulcer cured, the particles didn't shift, hemogram didn't decline obviously.Conclusion ¹²⁵I seed among the tissue implanted forever for the unsuccessful case after radiography and chemotherapy supply a new therapeutic methods. In the neat future curative effect is exactly, toxic reaction is small, which can remedy the deficiency of the treatment for radiography and chemotherapy.