Abstract: Microdosimetry is a effective method to description of the spatial distribution of energy deposition, and play an important role in research of the neutron radiation protection and treatment. Microdosimetry can provide more detail and accurate information of spatial distribution and energy deposition in tissue for Boron Neutron Capture Therapy (BNCT) or neutron radiation protection. Some progression in experimental microdosimetry for neutron radiatin protection and treatment based on Tissue-equivalent proportional counters (TEPC).