Abstract: Objective Observe the relation between endothelin and coronary heart disease around percufaneous coronary intervention (PCI) operation. Methods In hospital the coronary heart disease patients collected blood from the vein in 3 days before PCI operation, the same day, postoperative half an hour or 1 days or 3 days, observe the change of endothelin in plasma. Results There are obvious differences between the endothelin which in the normal control group and 3 days before operative or the same day, having nothing difference with the half an hour postoperative group, the endothelin which in 3 days or 1 day postoperative is obviously higher than the normal control group, the endothelin of half an hour postoperative is obviously lower than foreoporation, having statistics meaning, but 1 or 3 days postoporative is no difference with foreoporative. Conclusions The endothelin is closely with coronary heart disease, but if it could be as judging the index of the PCI postoperative taking a favorable turn and prognosis also needs the further discussion.