Abstract: The typical management of painful bone metastases is radiation therapy and the graduated use of opiate analgesics. As the development of nuclear medicine,bone-seeking radiopharmaceuticals have been utilized in cancer treatment,especially in management painful bone metastases. ¹⁵³Sm-EDTMP (samarium 153 ethylenediaminetetramethylene phosphonate) offers a good choice of treating method in palliating pain, improving quality of life, decreasing the rate at which new painful sites develop, and decreasing management costs.