Abstract: Recently, multimodality treatment for cancer is used to improve the therapeutic re-sponse and prolongate survival of the patients.Radionuclides therapy is a promising technology as a comple-mental method of surgery, chemotherapy and external radiotherapy.The requirements for ra-dionuclide therapy are explicated in this paper.Radiopharmaceuticals including chemical drugs, radio-labeled col-loids and particles, as well as immunotherapeutic agents and peptides directed against ma-lignant tumor in clinical application are illustrated.