Abstract: ⁹⁹Tc^m-tetrofosmin as a positive indicator in oncology,⁹⁹Tc^m-tetrofosmin scintigraphy has high sensitivity,specificity and accuracy in diagnosis of primary breast cancer, of local recurrence and of axillary lymph node metastases.⁹⁹Tc^m-tetrofosmin can also be used to detect bone metastases and recurrence after surgery. Furthermore,⁹⁹Tc^m-tetrofosmin presents promising perspectives in sentinel lymph node detection and imaging, in function imag-ing of P-glycoprotein and in guiding a biopsy. Associated with other methods,⁹⁹Tc^m-tetrofosmin scintigraphy improves the accuracy of detecting breast cancer.