硼中子俘获治疗的辐射场特点与剂量估算

Characteristics of radiation field and dosimetry of born neutron capture therapy

  • 摘要: BNCT(硼中子俘获治疗)基于这样一种思想:10B的载体化合物会优先选择癌细胞作为靶而后与热中子反应,进而产生高能、短射程裂变产物α粒子和Li粒子。它是一种双重的靶向治疗方法。BNCT的治疗效果依赖于两个主要因素:源于10B(n,α)7Li核反应的高LET(传能线密度)粒子的生物效应和在靶细胞及其特异区域内的硼沉积。本文总结和探讨了BNCT的发展概况、辐射场的特点以及吸收剂量的计算方法。

     

    Abstract: Boron neutron capture therapy (BNCT) is based on the nuclear reaction that occurs when boron-10 is irradiated with low-energy thermal neutrons to yield alpha particles and recoiling lithium-7 nuclei which have high energy and shortrange. BNCT is a binary approach:a boron-labeled compound is administered that delivered high concentration of 10B of the target tumor relative to the surrounding tissues. The therapeutic efficiency of BNCT is depended upon RBE and LET of the reaction and particles and the boron selectivity to cancerous cells. The development of BNCT, characteristic of radiation fields and calculations of energy deposition are described in this paper.

     

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