Abstract: Integral PET-CT implemented the unity of anatomy and function. It brings great improvement to the capability of imaging diagnosis and more accuracy information of diagnose and staging, assessment of therapy response and focal localization of radiotherapy on tumors. But it needs to standard the protocols of examination and exam patients according to clinical situation strictly when we have to educe the most diagnostic utility from this imaging modality and avoid the redundant radiant exposure on patients as possible as we can. Discussed some alternative problems about protocols of PET-CT on chest and abdomen tumors such as whole-body or toposcopy, body-position, if contrast agent is need, breathing control, thinking about radiation exposure, dual phase imaging and so on.