Abstract: Radioimmunotherapy (RIT)has superiority in treatment of cancer.the application of high energy α emmiter,β emmiter,electron capture radioisotopes and anti-cancer target carriers bring an innovation of RIT drugs.In this paper,it describes in detail the advances in radionuclide for RIT in the therapy of cancer and introduces the radionuclides,compares their advantages and disadvantages,and finally discusses the problems,potential solutions and directions in developing of radionuclide for RIT.