Abstract: Fibroblast-activated protein (FAP) is overexpressed in the tumor stroma. In recent years, ⁶⁸Ga-labelled FAP inhibitors (FAPI) have been widely used in clinical research, it has certain advantages in the diagnosis of digestive system malignant tumors, the evaluation of distant metastasis, and the assistance of delineate target volume. In this paper reviews the research progress of ⁶⁸Ga-FAPI PET/CT in common digestive system malignant tumours, in order to provide a reference for clinicians in the diagnosis and treatment of digestive system malignant tumors.