Abstract: The available detecting methods such as X-ray angiography, IVUS, OCT, B-Mode ultrasound, EBCT, MRI, thermometry all have their special value in displaying vascular constriction, thickening and plaque volume when used in the diagnosis of atherosclerotic plaque. The extensive application on clinic is limited because of either the invasive feature, or the limitation that only can displaying calcification, or the method, which can't reveal the early stage lesion characterized by metabolism disorder. The imaging using the nuclide labeled substance participating in atherosclerosis can reveal plaque components and metabolism status precisely and quantificationally, which brings in promise of noninvasively displaying atherosclerotic plaque, and has expansive application foreground in disease screening, therapeutic decision-making, effect observation and follow-up study.