Abstract: Along with the rapid development of PET and PET-CT technologies,the application of ¹⁸F-labelled radiopharmaeeuticals is more and more widespread in clinic.¹⁸F has predominant physical features with long half-life (110min).Also,the chemical nature of ¹⁸F is similar to that of hydrogen,it can't change the labelled molecular's character obviously.Therefore,the ¹⁸F is the best choice of radionuclide used in PET. However,natural animo acid has the character of metabolizing easily and complexly,the studies in non-natmal animo acid have increased gradually such as tyrosine derivatives,phenylalanine derivatives,praline derivatives,methionine derivatives,and so on.The article summarizes the ¹⁸F-labelled non.natural amino acids and their derivatives studied in recent years.