Abstract: Radioiodine labeled monoclonal antibodies have been widely used in the diagnosis and treatment of diseases.With the more and more attention which is attached to the application of the internalized McAb.The usual direct labeling methods, including Iodogen and chloramine-T, lead to obvious deiodination and decline of the McAb's immunological activity which impede their utilization in vivo.There is great importance for the tumor treatment with the radioiodine labeled antibodies to invent a new method in order to avoid the disadvantage described above.It is showed that indirect labeling way is a suitable strategy.In this review, we are introducing the recent advance of this method.