Abstract: Objective To investigate the valve of ¹³¹I-whole body scan (¹³¹I-WBS) and thyroglobulin(Tg) on the differentiated thyroid carcinoma with ¹³¹I.Methods The first ablation thyroid emnant at after thyroidectomy 4-6 weeks for all patients reseived ¹³¹I 1.11 GBq, 1.85 GBq, 2.96 GBq, 3.7 GBq, respratery. The metestases patients retreatment was after 3-6 months, ¹³¹I single doses rangging from 4.81-7.40 GBq. All patients were performed ¹³¹I-WBS and measured serum Tg.Results 28 patients (71.8%) had successful ablation remnant tissue at first therapy. 11 patients have been found metastases in first thrapy. The effection of tretment were best for patients with lymph metastases, and the patients of lung metastases were better, there was no significant effect for patients with bone metastases. Tg measurements were 20.5% cases inconsistent with ¹³¹I-WBS.Conclusions ¹³¹I therapy is an effective methoud to treat the patients with differentiated thyroid carcinomatous metastases and enhance the patients' livability. The mensuration of ¹³¹I-WBS and Tg should be combined operate to recruit reciprocally.