Abstract: Objective To detect the level of serum interleukin-6(IL-6)and insulin-lide growth factor-1(IGF-1)in patients with thyroid eye disease and to seek the rehtionship between serum level and the outbreak as well as the condition variety.Methods To measure the level of serumm IL-6 and IGF-1 by radioimmunoassay in 30 patients with thyroid eye disease after their clinical expression and activity Score have been assessed,30 patients with hyperthyroidism but without ophthalmopathy,30 healthy subjects.Results The level of serum IL-6 and IGF-1 in patients with thyroid eye disease were higher than that of patients with hyperthyroidism but without ophthalmopathy(t-4.20、t-4.00,P<0.01)and healthy subjects (t-4.20、t-4.05,P<0.01).IL-6 andIGF-1 levels tend to elevate With the increase of severity of eye disease.There were significant differedces among them.Conclusion The leve of IL-6,IGF-1 and the Cause of thyroid eye disease are closely related,and IL-6 and IGF-1 levels in peripheral blood might reflect the severity ofeye disease.