Abstract: Cancer of the pancreas remains a formidable challenge in oncology presently. It has unique advantages to treat pancreatic cancer by radioactive seeds because it has many physical and biological characteristics. The seed irradiator designed and built is very efficient and effective and has already been used extensively in radiobiological experiments and the accuracy of dosimetry. From reported clinical results, interstitial brachytherapy for pancreatic cancer can control tumor, relieve pain, improve quality of life and survival. It is an important modality in the treatment of pancreatic cancer.