Abstract: Resistin, a peptide cell factor secreted by fat cells, has wide distributiion in human body and multiple functions. Although resistin probably is a bridge connecting obesity to insulin resistance and diabetes, there are lots of controversies and disconformations among recent studies. So far, the detection method of resistin is enzyme linked immunosorbent assay, relative quantitative real-time PCR,radioimmunoassay and Western blotting. There was a statistically significant difference in serum resistin levels between the groups (breast cancer group 5.23±6.90 mg/L vs. control 1.46±2.00 mg/L). The studies of resistin in application in tumor nuclear medicine will investigate the relationgship of resistin and breast cancer further in the molecular level.