Abstract: The most useful colloidal rhenium can be classified into two kinds according to its radionu-clide:the 188 Re labelled colloid and the colloidal rhenium labeled with other radionuclide. Rhenium-188 sulphur colloid has been shown to be an effective treatment as a radiation synovectomy agent. ¹⁸⁸Re-labeled colloid, in addition was used to evaluate the effectiveness of this agent on some tumors such as melanoma, liver cancer in mice. For mapping sentinel nodes in lymphoscintigraphy, ⁹⁹Tc^m labeled rhenium colloid is a suitabl agent.