Abstract: The disadvantag e of radioimmunoassay are radio comtamination and can't automatied. In the date, the labelling immunoassay (enzyme immunoassay, fluorescent immunoassay. luminescent immunoassay) will eventually replace radioim-munoassay. This article reviews the clinical application of in the cardiov ascular disease by labelling immunoassay thy roid hormone (TH), endothelin(ET), cy tokine(CK), collagen, aminoterminal propeptide of typeⅢ procollag en(PⅢ NP), telopeptide of type I collagen (ICT P), myoglobin(Mb, cytokine isoenzyme cardiomuscle troponin I), g rowth hormone(GH), c-reactiv e protein(CRP), tumor necrosis factor-α (TNF-α), carbo thydrate antigen-125(CA-125),neuropeptide Y (NPY) and it's progress.