Abstract: The therapeutic radionuclides used for bone pain palliation, ⁸⁹Sr,¹⁵³Sm,¹⁸⁶Re,¹⁸⁸Re and ¹¹⁷Sn^m, were introduced. The production of these nuclides and the application for bone pain palliation have been reviewed. Specific advantages and disadvantages for each of these radionuclides have been discussed.