Abstract: Objective To investigate the links between expression and function of adhesive molecule on the surface of irradiated peripheral blood white cells.Methods Heparinized human peripheral blood was exposed to γ rays with different dose.At the different post-radiation time adhesive molecule expression on cellular surface was determined by double fluorescence labeling antibodies which were against adhesive molecule and special mark of granulocyte or mononuclear cell respectively with flow cytometry,and ceUular adhesive ability to different matrixes mediated by adhesive molecule WaS estimated by commercializing enzyme-linked inununosorbent assay kit and crystalviolet dying.Results A decline pattern of CD11b on surface ofmononuelear cells and CD29 on surface of granulocyte with irradiation dose increase was found.The changes of adhesive ability of mononuclear ceHs to substance of β1-integrin and collagen-I Was well related with irradiation dose.Conclusion Good relationship shown by the changes of adhesive molecule expression and adhesive ability mediated by the molecules on the surface of peripheral blood white cells with radiation dose was primary base of further research on indicting exposure dose by biomarker.