Abstract: The expression of erythropoietin and its receptor is very close related with the hypoxia status in tumor tissues. There are plenty of erythropoietin and erythropoietin receptor in the solid tumors. They are correlative with the resistance to the radiotherapy and chemotherapy. They also promote the invasive and migration. In clinical, there are more than an half of patients with tumor suffering from various extent of anaemia during the process of developing and treating the tumors, It is need to further investigate the use of erythropoietin in tumor patients.