Abstract: Glucaric acid (GLA) is a six-carbon dicarboxylic acid sugar, one of the natural endogenous end-eatabolite of glueose, whieh is normally present in tissues and body fluids. It ean be labeled with ^99mTc. In this review we diseuss the synthesis of GLA and the investigation of ^99mTc-GLA inelude the preparation of the kit, myocardiol infarction imaging and some tumor imaging (espeeially in breast tumor imaging). All the researches suggest that ^99mTc-GLA is a potential imaging for myocardiol infarction imaging and tumor imaging.