低剂量照射在肿瘤治疗中的应用研究进展

Advance of treatment in tumor by low-dose radiation

  • 摘要: 电离辐射生物效应与辐射剂量和剂量率有关,大、中剂量照射以损伤效应为主,低剂量照射可诱导机体的兴奋效应、适应性反应、超敏感性、旁效应等。低剂量全身照射通过诱导免疫增强效应、超敏感性、激活抗氧化酶系统及肿瘤细胞凋亡等机制具有抗肿瘤作用,降低随后较大剂量辐射诱发的肿瘤发生率。目前。低剂量照射在肿瘤防治中的应用正成为研究的热点。

     

    Abstract: The biological effects of ionizing irradiation is related with dose and dose-rate.Medium to large dose irradiation can induce damaging effect to biosystem.but low dose radiation may induce adaptive response,hormesis,hyper.sensitiVeness and bystander effeeL Especially experimental data suggest that the antitumor effects of immune enhancement,intrinsic hypersensitivity,activation antioxidase enzymatic system and induction of apoptosis is produced by low-dose total body irradiation.Furthermore it call decrease relative cancer risk in exposed populations.Therefore.the antitumor effect by low-dose irradiation is being widely investigated and intensively researched.

     

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