99mTc-MIBI联合99mTc-HL91乏氧显像对60例原发性肺癌的诊断评价

The diagnostic value of 99mTc-MIBI combined with 99mTc-HL91 hypoxia imaging in primary lung cancer

    摘要
  • 摘要: 目的 探讨99mTc-甲氧基异丁基异腈(99mTc-MIBI)肺亲肿瘤显像联合99mTc-4,9-二氮-3,3,10,10-四甲基十二烷-2,11-二酮肟(99mTc-HL91)乏氧显像对原发性肺癌的诊断效能。方法 对60例拟诊断原发性肺癌患者,术前进行99mTc-MIBI及99mTc-HL91显像,以病理结果为金标准,分析99mTc-MIBI联合99mTc-HL91显像对原发性肺癌的诊断价值。结果 病理结果证实原发性肺癌48例,良性病变12例。99mTc-MIBI、99mTc-HL91和99mTc-MIBI+99mTc-HL91显像对原发性肺癌诊断的灵敏度、特异度和准确率分别为89.6%(43/48)、77.1%(37/48)、95.8%(46/48),75.0%(9/12)、91.7%(11/12)、83.3%(10/12)和86.7%(52/60)、80.0%(48/60)、93.3%(56/60)。结论 99mTc-MIBI肺亲肿瘤显像联合99mTc-HL91乏氧显像有助于提高对原发性肺癌的诊断效能。

     

    Abstract: Objective To assess the diagnostic value of 99mTc-sestamibi (99mTc-MIBI)combined with 99mTc-labeled 4,9-diaza-3,3,10,10-tetramethyldodecan-2,11-dione dioxime (99mTc-HL91) hypoxia imaging in primary lung cancer. Methods 60 patients with suspicious lung tumours underwent 99mTc-MIBI and 99mTc-HL91 imaging before operation. The diagnosis were confirmed with pathological study after surgeries. The diagnostic effectiveness of 99mTc-MIBI and 99mTc-HL91 in primary lung cancer were analyzed. Results 48 patients were found primary lung cancer with pathological study, other 12 patients were benign. The sensitivity, speccifity and accuracy obtained with 99mTc-MIBI, 99mTc-HL91 imaging and the combination of two methods were 89.6%(43/48), 77.1%(37/48), 95.8%(46/48); 75.0%(9/12), 91.7%(56/60), 83.3%(10/12) and 86.7%(52/60), 80.0%(48/60), 93.3%(56/60), respectively. Conclusion The combination of 99mTc-MIBI and 99mTc-HL91 hypoxia imaging may increase the the diagnostic effectiveness in primary lung cancer.

     

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