低剂量辐射兴奋效应的研究及临床应用

赵欣然; 姜恩海; 李进; 刘强; 邢志伟; 江波; 王晓光; 姜立平

低剂量辐射兴奋效应的研究及临床应用

赵欣然 , 姜恩海 , 李进 , 刘强 , 邢志伟 , 江波 , 王晓光 , 姜立平

文章导航 > 国际放射医学核医学杂志 > 2008, 32 > 2: (114-117)

引用本文:

Citation:

低剂量辐射兴奋效应的研究及临床应用

300192 天津, 中国医学科学院放射医学研究所临床部
基金项目:
天津市自然科学基金项目(07JCYBJC09200)

Study on excited effect of low dose radiation and clinical application

Department of Clinic, Institute of Radiation Medicine, Chinese Academy of Medical Science, Tianjin 300192, China

摘要: 电离辐射广泛存在于人们的生活环境中,低剂量辐射可诱发机体产生适应性反应,其机制包括DNA损伤修复、促进T细胞内信息传递、保护性蛋白的产生、反应性氧类的作用,还能增强免疫力、抑制肿瘤的生长和转移及对化疗不良反应产生影响,具有肿瘤治疗的潜在临床意义。
- 剂量效应关系,辐射 /
- 肿瘤 /
- 辐射适应性反应
Abstract: Ionizing radiation exist extensively in life environment. Low dose radiation can induce adaptive response of the body, the mechanism including DNA damage repair, promote intracellular information transfer of T cell, the produce of protective protein and the effection of reactive oxygen species. It also can enhance immunity, inhibit growth and metastasis of tumor and can effect the adverse reaction of chemotherapy.
- Dose-effeetrelation, radiation /
- Neoplasms /
- Radiation of adaptive response
本作品遵循Signature-Non-Commercial Use 4.0 International (CC BY-NC 4.0)协议

[1]	Horsfall DJ, Tilley WD, Orell SR, et al. Relationship between ploidy and steroid hormone receptors in primary invasive breast cancer[J]. Br J Cancer, 1986, 53(1):23-28.
[2]	Zhou PK, Rigaud O. Down-regulation of the human CDC16 gene after exposure to ionizing radiation:A possible role in the radioadaptive response[J]. Radiat Res, 2001, 155(1pt1):43-49.
[3]	Sasaki MS, Ejima Y, Tachibana A, et al. DNA damage response pathway in radioadaptive response[J]. Mutat Res, 2002, 504(1-2):101-118.
[4]	Pastwa E, Blasiak J. Non-homologous DNA end joining[J]. Acta Biochim Pol, 2003, 50(4):891-908.
[5]	Liu SZ, Bai O. On meehaniestie studies of immune responses following low dose ionizing radiation.Intenrati onal meeting on biological effects of low dose radiation[C]. Amsterdam:Elsevire Science, 2000:129-135.
[6]	Stadler I, Evans R, Kolb B, et al. In vitro effects of low-level laser irradiation at 660 nm on peripheral blood lymphocytes[J]. Lasers Surg Med, 2000, 27(3):255-261.
[7]	Chen SL, Cai L, Meng Qy, et al. Low dose whole-body irradiation (LD-WBI)changes protein expression of mouse thymocytes:effect of a LD-WBI-enchanced protein RIP10 on cell proliferation and spontaneous or radiation induced thymocyte apoptosis[J]. Toxicol Sci, 2000, 55(1):97-106.
[8]	Feinendegen LE. Reactive oxygen species in cell responses to toxic agents[J]. Hum Exp Toxieol, 2002, 21(2):85-90.
[9]	赵建东,安永恒,周仁祥.不同吸氧方式对小鼠小肠上皮放射效应的影响[J].齐鲁医学杂志,2003,18(3):241-244.
[10]	Kojima S, Nakayama K, Ishida H. Low dose gammarays activate immune functions via induction of glutathione and delay tumor growth[J]. J Radiat Res(Tokyo), 2004, 45(1):33-39.
[11]	刘树峥.辐射免疫学研究的回顾与展望[J].中华放射医学与防护杂志,2005,25(2):193-200.
[12]	Safwat A, Aggerholm N, Roitt I, et al. Low-dose total body irradiation augments the therapeutic effect of interleukin-2 in a mouse model for metastatic malignant melanoma[J]. J Exp Ther Oncol, 2003, 3(4):161-168.
[13]	Kroger LA, DeNardo GL, Gumerlock PH, et a l. Apoptosis-related gene and protein expression in human lymphoma xenografts(Raji) after low dose rate radiation using ⁶⁷Cu-21T-BAT-Lym-1 radioimmunotherapy[J]. Cancer Biother Radiopharm, 2001, 16(3):213-225.
[14]	Mirzaie-Joniani H, Eriksson D, Sheikholvaezin A, et al. Apoptosis induced by low-dose and low-dose-rate radiation[J]. Cancer, 2002, 94(4 Suppl):1210-1214.
[15]	Mirzaie-Joniani H, Eriksson D, Johansson A, et al. Apoptosis in Hela Hep2 cells is induced by low-dose, low-dose-rate radiation[J]. Radiat Res, 2002, 158(5):634-640.
[16]	Szostak MJ, Kaur P, Amin P, et al. Apoptosis and bcl-2 expression in prostate cancer:significance in clinical outcome after brachytheray[J]. J Urol, 2001, 165(6pt1):2126-2130.
[17]	Winthrop MD, DeNardo SJ, Muenzer JT, et al. p53-independent response of a human breast carcinoma xenograft to radioimmunotherapy[J]. Cancer, 1997, 80(12 Suppl):2529-2537.
[18]	Brantley MA Jr, Worley L, Harbour JW. Altered expression of Rb and p53 in uveal melanomas following plaque radiotherapy[J]. Am J Ophthalmol, 2002, 133(2):242-248.
[19]	李涛,郎锦义,卢铀,等.低剂量分次照射脾脏对食管癌放疗患者细胞免疫功能的影响[J].临床肿瘤学杂志,2003,8(3):173-175.
[20]	Safwat A, Bayoumi Y, Akkoush H, et al. A phase Ⅱ trial of adjuvant low-dose total body irradiation in non-Hodgkin's lymphoma patients following standard CHOP[J]. Acta Oncol, 2004, 43(5):480-485.

[1]	赵红光 , 蔡露 , 龚守良 . 低剂量辐射与糖尿病. 国际放射医学核医学杂志, 2006, 30(1): 59-62.
[2]	杨岩 , 王娟 , 王冠军 . 低剂量辐射对人骨髓间充质干细胞影响的研究. 国际放射医学核医学杂志, 2008, 32(3): 183-187.
[3]	穆蕊 , 陈英 . 分子辐射生物剂量计发展潜势. 国际放射医学核医学杂志, 2008, 32(2): 109-113.
[4]	刘青杰 , 桑璐 . 线粒体DNA与肿瘤、辐射生物效应和衰老关系的研究现状. 国际放射医学核医学杂志, 2004, 28(2): 78-81.
[5]	李秀娟 , 李修义 . 低水平辐射兴奋效应与肿瘤. 国际放射医学核医学杂志, 1999, 23(2): 89-91.
[6]	王铭蔚 , 王蕊 , 衣峻萱 , 金顺子 . Hippo信号通路的调控机制及其在肿瘤细胞辐射效应中作用的研究进展. 国际放射医学核医学杂志, 2022, 46(12): 765-772. doi: 10.3760/cma.j.cn121381-202204004-00250
[7]	徐金苹 , 袁德晓 , 张江虹 , 邵春林 . 辐射诱导的外泌体在肿瘤细胞侵袭转移中的作用. 国际放射医学核医学杂志, 2015, 39(2): 144-148. doi: 10.3760/cma.j.issn.1673-4114.2015.02.009
[8]	默芳 , 张江虹 , 邵春林 . 乏氧微环境下外泌体对肿瘤进展及辐射抵抗的影响. 国际放射医学核医学杂志, 2019, 43(5): 450-455. doi: 10.3760/cma.j.issn.1673-4114.2019.05.012
[9]	金问森 , 金一尊 . 整合素介导的细胞信号转导与肿瘤辐射敏感性. 国际放射医学核医学杂志, 2006, 30(4): 237-239.
[10]	李玉 , 董丹 , 阎英 . 肿瘤辐射增敏机制研究进展. 国际放射医学核医学杂志, 2007, 31(1): 48-50.