Abstract: Bis N-ethoxy, N-ethyl (dithiocarbamato) nitrido Tc (V) (⁹⁹Tc^m-^N-NOET) is a neutral lipophilic tech-netium agent of myocardial perfusion presenting the high first-pass myocardial uptake and long myocardial retention. The location of ⁹⁹Tc^m-N-NOET myocardial uptake is on cell membranes, and its myocardial uptake is not en-ergy-dependent, which is affected by L-type calcium channel inhibitor.⁹⁹Tc^m-N-NOET not only has a myocardial redistribution equivalent to ²⁰¹Tl, the sensitivity and specificity of its myocardial perfusion imaging in detecting coronary artery disease but also are similar to ²⁰¹Tl.