Abstract: The physico-chemical characters of depleted uranium (DU) and their aerosol, the DU mass intaked by army-men in the battlefield, and the radiation dose and potential risk of servicemen induced bDU intake were assessed, which was addressed to the application of DU weapons in the war. The results of epidemic studies for groups exposed by DU were briefly introduced and the environmental effect from application of DU ammunition was discussed, too. Finally, the items that should be strengthened to study in future were suggested.