131I对甲状腺细胞凋亡的影响
The role of 131I on apoptosis of thyrocytes in vitro
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摘要: 由于每个患者特异性基因决定的个体辐射敏感性不同,使得每个接受131I治疗的患者对治疗的反应不一,因而疗效差异较大。针对不同的个体,采用不同的剂量治疗才可以提高131I治疗的效率,降低甲状腺功能减退症的发病率。通过目前的分子生物学技术,我们已经了解到一些基因的蛋白表达产物(Fas/FasL、Bcl-2等)与细胞凋亡和射线诱导凋亡的联系,使对凋亡基因表达产物的体外监测成为可能。也许通过对这些指标的监测,可以使我们在131I治疗过程中实现对不同的个体给予恰当的个体剂量。Abstract: The individual sensitivity of radiation is determined by specialized gene of people, so the patient with different radiotherapy dose has different results. Coinciding every patient with individual dose can improve the effect of radiotherapy, lower the incidence of hypothyroidism. Using modern molecular biology techniques, we have understood the relationships between several genes' products (Fas/FasL and Bcl-2 et al.) and apoptosis (or rays induced apoptosis), and all these methods and techniques make it possible for us to measure the products in vitro. Maybe in the future we can measure the index during the period of radiotherapy and use the suitable dose.