辐射对骨髓造血微环境影响的研究进展

Curent developments in the study of effects of irradiation on bone marrow haematopoietic microenvironment

摘要: 骨髓造血完全依赖骨髓微环境的支持和调控,早期和近期的观察均提出了辐射对骨髓造血微环境基质细胞的远期影响,并发现在某些实验条件下,辐射后基质细胞的集落刺激能力上升,生长因子(如GM-GSF)和粘附分子(如VCAM-1)表达升高。

Abstract: Hemotopoiesis completely depends on the regulation of the microenvironment. It has been indicated in the early and recent study the long-term effects of radiation on bone marrow microenvironment. It has been found in some experiments that after radiation the colony stimulating activity, the expression of growth factor (GMCSF) and adhesion molecule(V CAM-1) of the stroma cells was elevated.