Abstract: Depleted mallium (DU) is a byproduct of the uranium enrichment for producing nuclear reactor or nuclear weapon.DU is used in the military as an armor-piercing projectile due to its hardness, strength, and density.A lot of DU weapons were fired in the Gulf War, and bring about critical environmsntal and intemal contamination.Therefore, DU becomes suddenly a hot issue.In this paper, some toxicological problems after DU weapons attacked have been reviewed, which include features of iaternal DU contamination.hazard of wound contamination and inhalation with insoluble uranium, and other urgent toxicological issues.The healthy effects of implanted with depleted uranium pellets were illustrated in pahicular.