Abstract: Objective To investigate the effect of stereotatic radiotherapy (SRT) for brain metastases. Methods Retrospect compare 66 patients treated by SRT with whole brain radiotherapy (WBRT+ SRT) to 26 patients treated by SRT alone, Results The patients treated by WBRT+ SRT had significantly benefit in lesions recurrence (13,3% vs 42.2%), middle recurrence time (10.5 months vs 4.2 months) and middle survival time(13 months vs 6.5 months) over the patients treated by SRT, respectively (P<0.05), But there are no different in terms of improving of Karnofsky score, effective rate, one-year survival rate, one-year death rate between the two groups. Conclusion WBRT+ SRT play an important role in treating brain metastases, by improving patients' life quantity and reducing recurrence.