Abstract: Objective To analyze MRI characteristic features of tuberous sclerosis.Methods There are 14 patients were examined by MR routine scan and 3 patients with enhancement, all patients were proven by clinical examination.Results Subependymal nodules, were detected in all cases, which were most commonly along the lateral wall of the lateral ventricles. Cortical tubers were detected in 10 cases, the patterns of cortical tubers were gyral core lesion and H-shaped lesion on MRI. The abnormal findings of white matter were radial linear or wedge-shaped or irregular type on MR images. Subependymal giant cell astrocytomas were detected in 2 cases, renal angiomyolipoma was detected in 1 case.Conclusions MRI is sensitive to find the changes in imaging diagnosis of TSC and is the first choice among the diagnostic imaging modalities. T₁-weighted imaging (T₁WI) and gradient echo sequences are more sensitive to the subependymal nodules than T₂-weighted imaging (T₂WI). T₂WI and fluid-attenuated inversion recovery (FLAIR) are more sensitive to find the cortical tubers and abnormal white matter than T₁WI.