Abstract: Objective To research radiation protective nursing intervene and important notice of ¹²⁵I seeds minimally invasive implantation in non-small cell lung carcinoma(NSCLC)by CT.Methods Under the system of therapy planning system(TPS)and posologic validation, ¹²⁵I seeds were implanted in 89 cases of NSCLC patients.The consistent radiation protective nursing intervene was used in perioperative period management.The operative successful rate,therapeutic effect and complication rate was observed.Results The scientific radiation protective nursing intervene can ensure that the radioactive dose distribution of ¹²⁵I seed implantation brachytherapy is consistent with the principles of effective and minimally invasive.The operative successful rate was 100%.The local control rate and 1 year survival rate respectively was 97.4%and 92.2%.But the early and later incidence rate of radioactive damaging effect was 14.6% and 1.1%respectively.Leakage of radioactive contamination has not occurred.Conclusion The consistent TPS and posologic validation ¹²⁵I seeds implantation integrated scientific radiation protective nursing intervene.It is very important to improve the therapeutic effect of NSCLC and reduce the incidence of complications.