Abstract: Assessing physiological function of coronary arteries is helpful to objectively assess the risk stratification of coronary artery disease (CAD) and select appropriate treatment strategies for improving the prognosis of patients with CAD. Current clinical indicators used to evaluate the physiological function of coronary arteries include fractional flow reserve (FFR), myocardial flow reserve (MFR) and index of microciculatory resistance (IMR), which can be obtained by noninvasive or invasive methods. This article review the clinical values of FFR, MFR and IMR in patients with CAD.