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乏氧是许多实体肿瘤的显著特征,肿瘤乏氧微环境的产生及演变往往对于肿瘤细胞具有复杂且重要的影响。参与形成及维持肿瘤乏氧微环境的因素有很多,近年来的研究表明[1],外泌体作为肿瘤乏氧微环境的重要组成部分,在肿瘤细胞的生长、增殖、转移过程中均扮演着重要角色。乏氧微环境下外泌体的存在不仅能够增强肿瘤细胞的侵袭、迁移能力,影响肿瘤的血管生成,还能调节机体的免疫功能,改变肿瘤细胞的辐射敏感性与耐药性,从而促进肿瘤的恶化程度,降低肿瘤的治疗效果。本文就乏氧微环境下外泌体对肿瘤的发生发展及其对乏氧辐射抵抗的影响进行概述。
乏氧微环境下外泌体对肿瘤进展及辐射抵抗的影响
The effect of exosome in hypoxic microenvironment on tumor progression and radioresistance
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摘要: 肿瘤的发生发展是一个复杂的生物学过程,涉及诸多的因素。乏氧是实体肿瘤微环境的显著特征之一,乏氧微环境可导致肿瘤的适应性更强、恶性程度更高并产生耐药性。研究发现,外泌体是介导肿瘤生物学过程的重要因子,而乏氧环境下产生的外泌体在某些生物学过程中的作用更为显著。因而,研究乏氧环境下外泌体对了解肿瘤的发展进程,控制肿瘤的生长具有重要意义。笔者简单概述了外泌体在肿瘤乏氧微环境中的作用,以期为肿瘤生物学的研究提供一定的理论基础。Abstract: The development and progression of tumor is a complex biological process, involving many factors. Hypoxia is one of the prominent features of the microenvironment of solid tumors. Hypoxic microenvironment can contribute to tumors with stronger adaptability, higher malignancy and drug-resistance. The study found that exosomes are important factors in mediating tumor biological processes, while hypoxic-derived exosomes play a more prominent role in some biological processes. Therefore, researches on hypoxic-derived exosomes are of great importance in understanding the development and growth control of tumors. This article briefly outlines the role of exosomes in tumor hypoxic microenvironment, in order to provide a theoretical basis for the researches of tumor biology.
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Key words:
- Tumor hypoxia /
- Exosomes /
- Tumor /
- Radioresistance
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