Abstract: The development and progression of tumor is a complex biological process, involving many factors. Hypoxia is one of the prominent features of the microenvironment of solid tumors. Hypoxic microenvironment can contribute to tumors with stronger adaptability, higher malignancy and drug-resistance. The study found that exosomes are important factors in mediating tumor biological processes, while hypoxic-derived exosomes play a more prominent role in some biological processes. Therefore, researches on hypoxic-derived exosomes are of great importance in understanding the development and growth control of tumors. This article briefly outlines the role of exosomes in tumor hypoxic microenvironment, in order to provide a theoretical basis for the researches of tumor biology.