Objective To investigate the effects of stereotactic radiotherapy on the expression of serum carcinoembryonic antigen (CEA), glycoprotein antigen-125 (CA125), glycoprotein antigen-125 (CA153), and tumor specific growth factor (TSGF) in patients with advanced lung adenocarcinoma.

Methods Ninety-two patients with advanced lung adenocarcinoma admitted to Yantai Yantai m ountain hospital from January 2015 to May 2017 were equally and randomly divided into a control 46 cases: 28 males and 18 females with the average of (57.6±7.4) and an observation group 46 cases: 30 males and 16 females with the average of (58.2±8.1). The control group was treated with paclitaxel and cisplatin chemotherapy. Stereotactic radiotherapy was given on the basis of the group. The therapeutic effects; serum CEA, CA125, CA153, and TSGF expression levels; complications; and prognosis of the two groups were compared. χ² test and t test were used for the comparison among groups, and Kaplan Meier survival curve was used to analyze the survival rate.

Results The effective rates were 37.0% (17/46) and 17.4% (8/46) in the observation and the control group, respectively. The difference was significant (χ²=4.449, P=0.035). The expression levels of serum CEA, CA125, CA153, and TSGF in the observation group were significantly lower than those in the control group (t=6.987–13.575, all P=0.000). No significant difference was observed in terms of complications (χ²=0.562, P=0.337). The median survival times were 13.6 and 10.2 months in the observation and the control group, respectively. The difference was significant (U=126.0, P<0.01).

Conclusion Stereotactic radiography can promote lung adenocarcinoma therapy, reduce the level of serum tumor markers, and prolong the survival period of patients. Therefore, stereotactic radiography is worthy of clinical application.