Abstract: According to the current management policy in China, the regulations and workflow, to briefly discuss the relative problem about the site selection, layout design, waste treatment, radiation protection and the management of radionuclide treatment ward. To provide the proposal of the radionuclide treatment ward about establishment and radiation protection, as well as preliminary opinions on the management of ward. Then provide references and suggestions for establishing a radionuclide treatment ward in department of nuclear medicine of hospital.