Abstract: A solitary pulmonary nodule (SPN) is a single, well-circumscribed nodule with diameter less than 3 cm. The clinical manifestations and imaging features of SPN are usually atypical because of the small size and it is often found during physical examination. There are many kinds of benign SPN, including tuberculosis, hamartoma, sclerosing hemangioma, pulmonary inflammatory myofibroblastoma tumor and so on. Tuberculosis and pulmonary inflammatory myofiblastic tumor, which are easily misdiagnosed because of high uptake in PET/CT imaging, were selected. The clinical features and imaging manifestations of the two lesions were analyzed and reviewed in order to get inspiration and improve the diagnostic accuracy of benign SPN in future work.