Abstract: Differentiated thyroid carcinoma(DTC), which can be divided into papillary thyroid carcinoma and follicular thyroid carcinoma, is the most common malignant tumor of the endocrine system. Ultrasound of DTC features important clinical value. The treatment of DTC includes surgery, thyroid stimulating hormone-suppression, and ¹³¹I radiotherapy in vivo. DTC presents the highest incidence of thyroid cancer, and the value has increased annually in recent years. At the same time, new research have constantly put forward new viewpoints in diagnosis and treatment of DTC. The diagnosis and treatment of differentiated thyroid carcinoma were investigated and reviewed in this article.